Notes: - All games will be available Friday
- Green highlight indicates plus matchup (top eight)
- Red highlight indicates negative matchup (bottom eight)
- Injury notes, Lines and Totals updated Sunday morning
With Ricky Pearsall (knee) and Jauan Jennings (ankle/rib) sidelined,
along with Brandon Aiyuk and TE George Kittle, Kendrick Bourne
suddenly finds himself as San Francisco’s top healthy receiving
option outside of Christian McCaffrey.
Bourne has never topped 800 yards in a season during his nine-year
career, and he’s averaging just 4.3 targets per game in
2025. Still, necessity could drive increased involvement against
the Rams. The ceiling is low -- he’s best viewed as a WR4
-- but bye-week managers in deeper formats might find him serviceable.
With Brock Purdy (toe) out, Mac Jones inherits a depleted supporting
cast missing four of its top five weapons. That’s a brutal setup
against a Rams defense that’s held three of four opposing quarterbacks
under 15 fantasy points. Even with volume, Jones’ efficiency outlook
is poor, leaving him in the QB2/3 range and best left on benches.
SF FPts Allowed vs. QBs: No.29
SF FPts Allowed vs. RBs: No.26
SF FPts Allowed vs. WRs: No.29
SF FPts Allowed vs. TEs: No.9
The 49ers have stifled wide receivers, holding all but one opponent
wideout under 60 yards and allowing just two WR touchdowns across
four games. Davante Adams hasn’t exactly been lighting it
up either -- he’s topped 60 yards once, with most of his
fantasy appeal tied to three trips to the end zone.
That said, the Rams should control field position against a banged-up
49ers squad, which increases Adams’ red-zone outlook. He
remains a volume-driven WR2 with scoring upside, even in a difficult
matchup.
Rookie Blake Corum logged a career-high 11 touches in Week 4
and has averaged 9.5 touches across the past two games. Efficiency
hasn’t been the problem (5.2 YPC) -- it’s opportunity.
Against a 49ers team the Rams could overwhelm, Corum has a path
to expanded work late, making him an intriguing deep-league flex
with upside if game script tilts heavily in L.A.’s favor.
Matthew Stafford erupted for 375 yards and three touchdowns against
the Colts, but that outing stands in stark contrast to his quieter
lines versus Houston (13.6 fantasy points) and Philadelphia (15.8).
San Francisco has been similarly stingy, allowing no more than
207 passing yards in a game and giving up the 4th-fewest FPts/G
to quarterbacks.
With the Rams positioned to lean on their ground game and defense,
Stafford projects as a back-end QB2 and a fade in most fantasy
lineups.
