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San Francisco

Isaac Guerendo out for a while
RB expected to miss a few weeks with shoulder issue
By: Doug Orth | Aug 4 2025, 3:40 pm

49ers RB Isaac Guerendo is expected to miss “a few weeks” with a shoulder injury, per Kyle Shanahan. (ESPN - Adam Schefter)

FFToday's Take: Guerendo is no stranger to injuries. although hamstring issues have usually been his downfall. "A few weeks" is a vague timeline, but we can probably assume this injury will force him to miss every preseason game. While this injury may free up Christian McCaffrey to handle more of the early-season workload than most were expecting, it could also give rookie Jordan James a chance to make his case to be the No. 2 in San Francisco. James' preseason will be one to monitor as a result of this news.