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A popular breakout candidate heading into last season, Aiyuk frustrated fantasy owners by failing to reach the 50-yard plateau in any game over the first two months. He came to life on Nov. 7, catching six passes for 89 yards and a touchdown in a loss to Arizona. From then on, the Arizona State product was hit or miss, but he was at least playable. He closed the regular season on a high note, posting a season-high 107 yards in an overtime win over the Rams that landed San Francisco in the playoffs.
Aiyuk has primarily been a chain mover in his two years, averaging 13.6 yards on his 116 career grabs, but it'll be interesting to see if Lance's insertion in the lineup unlocks more big plays for the passing game in general and Aiyuk specifically. There's bound to be some blowback from fantasy owners that got burned a year ago, which could push the third-year pro down the draft board. If he falls far enough, Aiyuk would make an enticing target as a No. 4 fantasy wideout.
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 Deebo Samuel likely to miss about three weeks
Ankle and knee injuries
By: Doug Orth | Tue Dec 13, 11:30 pm
|  | 49ers’ HC Kyle Shanahan told reporters that he expects WR Deebo Samuel to return from his knee and ankle injuries in around three weeks. (ESPN - Adam Schefter)
FFToday's Take: It would not be a surprise if the 49ers end up giving Samuel the rest of the regular season to heal up so he can be in good health for the NFL postseason. In his absence, Brandon Aiyuk and George Kittle should be more involved in the passing game in Samuel's absence, which should also free up about five or six targets per game for Jauan Jennings. Fantasy managers in dire need of a roster space can probably drop Samuel, although such a move comes with some risk.
| Deebo Samuel injures ankle in Week 14
Avoided a major injury
By: Mike Krueger | Sun Dec 11, 7:07 pm
| | #49ers WR Deebo Samuel is believed to have avoided a major injury, per source. It's his ankle, not his knee. Still evaluating to learn more. (Tom Pelissero on Twitter)
FFToday's Take: Deebo was carted off after getting rolled up on against the Bucs. It sounds like he avoided a serious injury but it won't be shocking if he misses the next few weeks. San Francisco plays Thursday night in Week 15 at Seattle. Brandon Aiyuk would assume the No.1 receiving role if Deebo is out.
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