In 2025, the answer turned out to be quite easy to determine... after the fact. The Rams' Matthew Stafford finished second in fantasy-point-per-game (24.7) and his main man Puka Nacua ran away from every cornerback and receiver in leading all wideouts in scoring at 23.6 FPts/G. Together they combined for an amazing 48.3 fantasy points each week, more than five points better than any other duo.

But is that 48-point total repeatable? For Stafford, who was a 14th-round fantasy pick in 2025 (QB 23, ADP 160), it was a career-best season, throwing for 46 touchdowns. His 419.5 fantasy points was the second-best of his career and in this era of running fantasy quarterbacks... he rushed 29 times for one measly yard. Additionally, Nacua had career-best totals in targets (166), receptions (129), receiving yards (1,715), receiving touchdowns (10), rushing yards (105) and rushing touchdowns (1). Nacua was the seventh receiver off the board and 13th overall in 2025. Can he do that again even as Stafford gets more comfortable with Davante Adams? Remember last season Stafford and Adams didn't get much preseason practice time as Stafford was dealing with a bad back so they started slowly and grew together as the season progressed.

You will spend a bit more for this duo in 2026. Nacua is currently the No.2 player off the board (behind Ja'Marr Chase) and Stafford will cost you an 11th round selection. Obviously, you will need a top-two pick because Puka is going to be gone quickly, but I would certainly love to have this combination for 2026!

That said, who can challenge this quarterback-wide receiver combination?

Let's first start with the four other duos who cracked the 40-point mark and then we will look for some longer shots to give the Stafford-Nacua combo a run for their money.

2025 40-point Duos

1) Patrick Mahomes & Rashee Rice (42.8) – Both players finished the season on the sidelines. Mahomes blew out an ACL and LCL in Week 15 and is eyeing a return for Week 1, which would be impressive. Rice, began the season in Week 7 after a six–game suspension and produced four 20-point games before a concussion caused him to miss the final two games of 2025. Another "busy" off-season for Rice with a 30-day jail stint and clean-up surgery on his right knee. Ho hum. They will have no game practice heading to the season. And in the meantime, management brought in Super Bowl MVP Kenneth Walker to take pressure off his now less-mobile quarterback. Walker also has good hands as a receiver. The Chiefs still have a quality receiver across from Rice in Xavier Worthy and Mr. Taylor Swift a.k.a. Travis Kelce at tight end. I can't see this tandem producing even at last year's average.

2) Jared Goff & Amon-Ra St. Brown (40.8) – Amon-Ra St. Brown has the talent to be the top receiver in the league, as he's averaged over 18.5 FPts/G for the past three seasons. But the diversity of the Lions offense and the talent throughout limits his ceiling. Still, he's averaged 117 receptions and 11 touchdowns since 2023. The limiting factor against the pair of Goff and St. Brown is the talent in the backfield led by the elite Jahmyr Gibbs (21.7 FPts/G) and his fellow pass-catchers in Jameson Williams and tight end Sam LaPorta. Goff is pretty consistent in giving you about 22 FPts/G and it would be hard to feed "ARSB" more than the career-high 172 times he saw the ball in 2025. A solid pair, but not No.1.

3) Matthew Stafford & Davante Adams (40.6) – We already know about Stafford, but you should know that Adams has the ability to produce big numbers from his days in Green Bay. In this offense, however, he's become more touchdown dependent because Nacua and the various tight ends limit his target volume. Still, if something happens to Puka, Adams averaged 20.1 FPts/G when he caught five balls or more in a game. Adams' 50 ADP makes it easy to put him with Stafford, but Nacua makes this the Rams' second-best receiving option.

4) Joe Burrow & Ja'Marr Chase (40.0) – Despite finishing third among wideouts in FPts/G (19.7), Chase is being selected first overall in many leagues. They averaged 40.0 FPts/G for the season and from Week 13 to the end of the season they averaged 44.1 FPts/G. They can obviously put up big numbers, the primary question here is whether the Bengals OL can keep Burrow upright. It's 50-50… for real. He's played 16 or more in three seasons and 10 or less in three seasons.

Others

Sam Darnold & Jaxon Smith-Njigba – Smith-Njigba finished second to Nacua, averaging 21.3 FPts/G. But Sam Darnold is no Matthew Stafford. In eight seasons, Darnold has only cracked 20 FPts/G once, Stafford 12 times. So, even if he produced a career-best, JSN would likely need to produce 25% more. That's another 450 yards and three more touchdowns. On a team which likes to be balanced between running and passing and just drafted a running back in the first round, I'd have to say this duo is not going to be the top combo.

Dak Prescott & George Pickens/CeeDee Lamb – Prescott threw the ball 600 times for 4,500 yards and 30 touchdowns. That's pretty good. It was enough to support two top-10 fantasy receivers in Pickens (6th) and Lamb (10th). Part of that was Pickens taking advantage of four missed games from Lamb to average 24.1 FPts/G in his absence. Prescott (ADP 79) and one receiver might be able to compete, but with two, and Javonte Williams getting most of the goal line touchdowns, it would be hard to figure which receiver to choose. Lamb is the fifth receiver off the board in '26 drafts, while Pickens is going ninth.

Drake Maye & A.J. Brown – Maye had everything working in his favor last season. An easy schedule, a 1,000-yard receiver and four other pass catchers with at least 500 yards. They decided to go big in the off-season after being so close to the brass ring, getting rid of Stefon Diggs and trading for the Eagles A.J. Brown. Even in an off-year, Brown ranked 12th in FPts/G (14.7). Brown is going at the end of the second round. Going against them is a first-place schedule. They are not going 14-3 in 2026. The Pats start the season with the Super Bowl champions, then play Pittsburgh, Jacksonville and Buffalo. They will face the entire NFC North. And they have a very good pair of running backs in Rhamondre Stevenson and TreVeyon Henderson. They will run too much to vie for the top passing hookup.

Josh Allen & D.J. Moore – Moore had to share the spotlight in Chicago with two rookie receivers and two talented tight ends. After moving his address to Orchard Park, Moore will have a better chance to shine. He'll be the lead guy, with Khalil Shakir and Keon Coleman behind him. Moore will still have to deal with tight ends who can catch in Dalton Kincaid and Dawson Knox, but he'll average more than the 9.9 FPts/G he did last season with the Bears. He's capable of 15-17 FPts/G. That means his quarterback Josh Allen would need to have a superhuman effort and average close to 30 FPts/G. He's been as high as 29 FPts/G, twice, so it's certainly possible. Moore isn't getting much respect, as the 27th WR off the board, but you will obviously have to grab Allen early, he's going early in the third round as the No.1 quarterback.

Caleb Williams & Rome Odunze – Williams was much improved in his second year, raising his production by 3.3 FPts/G. He'll need to continue his upward trend. Additionally, we would need to see the Odunze who played the first four games of his career averaging 19.8 FPts/G. But with Moore in Buffalo, he should get plenty of targets as will Luther Burden III and tight end Colston Loveland. The Bears improved from 18.2 PPG in 2024 to 25.9 in 2025 which was ninth best in the league. Under HC Ben Johnson there is no reason they can't be a top-five offense. It would be a bit of a stretch to think they could equal Stafford-to-Nacua, but they could be a top-seven duo if everything goes right.